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N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-Glutamic acid

5-[2-(4-{[(1S)-4-ethoxy-1-(ethoxycarbonyl)-4-oxobutyl]carbamoyl}phenyl)ethyl]-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-2-aminium 4-methylbenzenesulfonate (non-preferred name)

CAS: 165049-28-5

Molecular Formula: C24H29N5O6.C7H8O3S

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  5. N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-Glutamic acid

N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-Glutamic acid - Names and Identifiers

Name 5-[2-(4-{[(1S)-4-ethoxy-1-(ethoxycarbonyl)-4-oxobutyl]carbamoyl}phenyl)ethyl]-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-2-aminium 4-methylbenzenesulfonate (non-preferred name)
Synonyms benzamido)
PeMetrexed disodiuM INT-5
N-[4-[2-(2-aMino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]L-glutaMic acid
(S)-Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pe
(S)-Diethyl 2-(4-(2-(2-aMino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioate 4-Methylbenzenesulfonate
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester 4-methylbenzenesulfonate
N-[4-[2-(2-Amino-4,7-Dihydro-4-Oxo-3h-Pyrrolo[2,3- D]Pyrimidin-5-Yl)Ethyl]Benzoyl]-L-Glutamic Acid-1,5-Diethyl Ester 4-Ethylbenzene Sulfonate
5-[2-(4-{[(1S)-4-ethoxy-1-(ethoxycarbonyl)-4-oxobutyl]carbamoyl}phenyl)ethyl]-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-2-aminium 4-methylbenzenesulfonate
5-[2-(4-{[(1S)-4-ethoxy-1-(ethoxycarbonyl)-4-oxobutyl]carbaMoyl}phenyl)ethyl]-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyriMidin-2-aMiniuM 4-Methylbenzenesulfonate (non-preferred naMe)
5-[2-(4-{[(1S)-4-ethoxy-1-(ethoxycarbonyl)-4-oxobutyl]carbamoyl}phenyl)ethyl]-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-2-aminium 4-methylbenzenesulfonate (non-preferred name)
CAS 165049-28-5
EINECS 605-383-3
InChI InChI=1/C24H29N5O6.C7H8O3S/c1-3-34-18(30)12-11-17(23(33)35-4-2)27-21(31)15-8-5-14(6-9-15)7-10-16-13-26-20-19(16)22(32)29-24(25)28-20;1-6-2-4-7(5-3-6)11(8,9)10/h5-6,8-9,13,17H,3-4,7,10-12H2,1-2H3,(H,27,31)(H4,25,26,28,29,32);2-5H,1H3,(H,8,9,10)/t17-;/m0./s1

N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-Glutamic acid - Physico-chemical Properties

Molecular FormulaC24H29N5O6.C7H8O3S
Molar Mass655.725
Melting Point>237oC (dec.)
Solubility Dichloromethane (Very Slightly), DMF (Slightly, Sonicated), DMSO (Slightly)
AppearanceSolid
ColorOff-White to Pale Brown
Storage ConditionKeep in dark place,Inert atmosphere,Room temperature

N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-Glutamic acid - Introduction

N-[4-[2-(2-amino -4, 7-dihydro-4-oxo-1h-pyrrole [2,3-d] pyrimidin-5-yl) ethyl] benzoyl]-L-glutamic acid Diethyl ester is an organic compound, also known as ADEPT, whose chemical structure contains Benzoyl, glutamic acid Diethyl ester and pyrrole [2,3-D] Pyrimidine structural unit. It is a white to pale yellow solid.

The main properties and uses of this substance are as follows:
1. Nature: it is soluble in organic solvents, and insoluble in water. It is a stable compound capable of long-term storage at room temperature.
2. Use: N-[4-[2-(2-amino -4, 7-dihydro-4-oxo-1h-pyrrole [2,3-d] pyrimidin-5-yl) ethyl] benzoyl]-L-glutamic acid Diethyl ester is mainly used as a drug carrier. It can be used to deliver antineoplastic drugs such as tosylate. Due to its special chemical structure, it can increase the selectivity and efficacy of drugs, while reducing the toxicity to normal cells.
3. Preparation: N-[4-[2-(2-amino -4, 7-dihydro-4-oxo-1h-pyrrole [2,3-d] pyrimidin-5-yl) ethyl] benzoyl]-L-glutamic acid Diethyl ester is obtained by chemical synthesis. Specific synthetic methods may involve multiple reactions and the use of specific reagents.
4. Safety information: Due to the lack of specific safety data, for N-[4-[2-(2-amino -4, 7-dihydro-4-oxo-1h-pyrrole [2, the safety of 3-D] pyrimidin-5-yl) ethyl] benzoyl]-L-glutamic acid Diethyl ester requires further study and evaluation. Appropriate laboratory safety practices and procedures should be followed when handling and using the compound, including wearing protective gloves, goggles and laboratory clothing to avoid direct contact with skin and inhalation of its dust. If necessary, work in a well-ventilated area.
Last Update：2024-04-09 19:05:47
N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-Glutamic acid
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Email: 2853786052@qq.com
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Product Name: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid 1 Visit Supplier Webpage Request for quotation
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N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-Glutamic acid
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